Spiro[1,3-dioxolane-2,4′-[8]phenylsulfonylbicyclo[4.2.0]octan-1-ol]
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چکیده
منابع مشابه
5-Aminopentan-1-ol
The title compound, C(5)H(13)NO, is an aliphatic amino-alcohol with both functional groups residing on terminal C atoms. Apart from the hy-droxy group, all non-H atoms are nearly co-planar, the maximum deviation of an atom taking part in the least-squares plane defined by the mentioned non-H atoms being 0.029 (1) Å. In the crystal, O-H⋯N and N-H⋯O hydrogen bonds connect the mol-ecules, forming ...
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In the essentially planar (r.m.s. deviation = 0.023 Å) title compound, C(10)H(6)Br(2)O, an intra-molecular O-H⋯Br hydrogen bond generates an S(5) ring. In the crystal, mol-ecules are linked by an ⋯O-H⋯O-H⋯O- C(2) chain extending along [100], which involves the same H atom that participates in the intra-molecular hydrogen bond. Aromatic π-π inter-actions [centroid-centroid separation = 3.737 (4)...
متن کامل2,5-Dibromoindan-1-ol
In the title compound, C(9)H(8)Br(2)O, the cyclo-pentene ring adopts an envelope conformation with the brominated C atom as the flap. In the crystal, mol-ecules are linked by strong O-H⋯O hydrogen bonds into zigzag C(4) chains along [010]. In addition, a C-H⋯π inter-action involving the benzene ring and the H atom attached to the hy-droxy-lated C atom is observed.
متن کاملMechanism of Action of 1-b-D-2,6-Diaminopurine Dioxolane, a Prodrug of the Human Immunodeficiency Virus Type 1 Inhibitor 1-b-D-Dioxolane Guanosine
PHILLIP A. FURMAN,* JERRY JEFFREY, LAURA L. KIEFER, JOY Y. FENG, KAREN S. ANDERSON, KATYNA BORROTO-ESODA, EDGAR HILL, WILLIAM C. COPELAND, CHUNG K. CHU, JEAN-PIERRE SOMMADOSSI, IRINA LIBERMAN, RAYMOND F. SCHINAZI, AND GEORGE R. PAINTER Triangle Pharmaceuticals, Durham, North Carolina 27707; Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520-8066; Laboratory of Mol...
متن کاملMechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
(-)-beta-D-2,6-Diaminopurine dioxolane (DAPD), is a nucleoside reverse transcriptase (RT) inhibitor with activity against human immunodeficiency virus type 1 (HIV-1). DAPD, which was designed as a water-soluble prodrug, is deaminated by adenosine deaminase to give (-)-beta-D-dioxolane guanine (DXG). By using calf adenosine deaminase a K(m) value of 15 +/- 0.7 microM was determined for DAPD, whi...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2003
ISSN: 1600-5368
DOI: 10.1107/s1600536803009735